Can Digestive Enzymes Be Taken With Antacids?

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Antacids and digestive enzymes can be used together to address digestive discomfort, as they target different aspects of digestion. Antacids neutralize excess stomach acid, while digestive enzymes aid in efficient digestion. However, the effectiveness of oral digestive enzymes may decrease when given with calcium or magnesium-containing antacids.

Digestive enzymes containing amylase or other carbohydrate are the most common and FDA-regulated enzyme supplements. They help the body process food and absorb nutrients better. Early research shows that taking digestive enzymes and increasing stomach acid with betaine hydrochloric acid (HCL) tablets may be all that is needed to relieve acid reflux.

Digestive enzyme supplements can interact with antacids and certain diabetes medications, causing side effects. It is important to avoid taking antacids or indigestion remedies within two hours of taking digestive enzymes, as these may reduce the enzymes’ effectiveness. Pancreatic enzymes may have reduced effectiveness if taken at the same time as calcium- or magnesium-containing antacids, such as Maalox®, Mylanta®, Tums®, or Maalox®.

The effectiveness of oral digestive enzymes may decrease when given with calcium or magnesium-containing antacids. Antacids are all known as proton pump inhibitors and can exacerbate problems in the digestive system. It is generally safe to take omeprazole and digestive enzymes together, but it is best to consult with a doctor before taking any medication.

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Is it okay to take digestive enzymes if you have acid reflux?

If you experience frequent or recurring stomach aches, diarrhea, acid reflux, gas, and bloating, you may wonder if taking a digestive enzyme supplement could help. But, over-the-counter supplements like these are not actually designed to treat gastrointestinal ailments, nor can they speed up metabolism.

What are digestive enzymes?. As part of the digestive process, your body produces various enzymes to chemically break down food’s proteins, sugars, fats and complex carbohydrates so these nutrients can be absorbed and used by the body.

  • Examples of digestive enzymes include:. Amylase : made in the mouth (salivary glands) and pancreas
  • breaks down complex carbohydrates
  • Lipase : made in the pancreas
  • breaks down fats
  • Protease : made in the stomach, pancreas and small intestine
  • breaks down proteins
  • Lactase : breaks down lactose, which is the sugar naturally occurring in dairy
  • Sucrase : breaks down sucrose, which is the naturally occurring sugar found in fruits and vegetables
What supplements should you not take with acid reflux?
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What supplements should you not take with acid reflux?

  • Antibiotics, such as tetracycline and clindamycin.
  • Bisphosphonates taken by mouth, such as alendronate (Binosto, Fosamax), ibandronate and risedronate (Actonel, Atelvia).
  • Iron supplements.
  • Quinidine.
  • Pain relievers, such as ibuprofen (Advil, Motrin IB, others) and aspirin.
  • Potassium supplements.

Medicines and dietary supplements that may increase acid reflux and worsen GERD include:

  • Anticholinergics, such as oxybutynin, prescribed for overactive bladder and irritable bowel syndrome.
  • Tricyclic antidepressants, such as amitriptyline, and doxepin (Silenor).
  • Calcium channel blockers, statins, angiotensin-converting enzyme (ACE) inhibitors, and nitrates used for high blood pressure and heart disease.
  • Narcotics, also called opioids, such as codeine, and those that have hydrocodone and acetaminophen.
  • Progesterone.
  • Sedatives or tranquilizers, including benzodiazepines such as diazepam (Valium) and temazepam (Restoril).
  • Theophylline (Elixophyllin, Theochron).

Do antacids interfere with supplements?

Vitamin C and antacids that contain aluminum can lead to toxic levels in the body when taken together, so they should be taken at least two hours apart. Vitamin E can increase the risk of bleeding when taken with blood-thinning medications like warfarin, so it’s important to consult a provider before starting. St. John’s Wort supplements can interact with various medications, reducing their effectiveness and causing harmful effects. Goldenseal supplements can reduce the body’s ability to clot blood, leading to bleeding or bruising. Ginkgo biloba supplements can also increase the risk of bleeding when taken with blood-thinning medications like warfarin or aspirin. Licorice root supplements can interact with diuretics and blood pressure medications, making their side effects worse or causing serious problems like potassium imbalances or blood pressure fluctuations. If you’re taking prescription medications and considering supplements, talk to your provider or pharmacist. Timing is crucial when taking these combinations, as thyroid hormone medications should be taken on an empty stomach and separated from supplements by at least four hours, especially if they contain calcium and iron.

Do digestive enzymes get rid of gas?
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Do digestive enzymes get rid of gas?

A. Digestive enzyme supplements purportedly fix all sorts of abdominal symptoms, including bloating, gas, and bowel irregularity, as well as overall gut health. However, for most people, there’s little evidence that they do any good.

Naturally occurring digestive enzymes help break down food so the body can soak up nutrients. Your mouth, stomach, and small intestine make some digestive enzymes. Still, most come from your pancreas, which floods the small intestine with enzymes when the food arrives there.

The main pancreatic enzymes are lipase, which breaks down fats; amylase, which breaks down carbohydrates; and proteases and peptidases, which break down proteins.

When is it too late to take digestive enzymes?
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When is it too late to take digestive enzymes?

As a result, replacement digestive enzymes can help prevent malabsorption and related digestive discomforts.

Because they’re meant to mimic your natural pancreatic enzymes, replacement digestive enzymes must be taken just before you eat. That way, they can do their work as food hits your stomach and small intestine.

In some cases, you may break up the dose. For example, if you’re eating a large meal that takes longer than usual to eat, or if you’re a slow eater, your doctor may recommend taking half the dose at the start of the meal and the rest halfway through your meal.

If you don’t take replacement digestive enzymes with food, they won’t be of much use.

What happens to your body when you start taking digestive enzymes?
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What happens to your body when you start taking digestive enzymes?

Replacement digestive enzymes take the place of natural enzymes, helping to break down carbohydrates, fats, and proteins from the foods you eat. Then the nutrients are absorbed into your body through the wall of the small intestine and distributed through the bloodstream.

As a result, replacement digestive enzymes can help prevent malabsorption and related digestive discomforts.

Because they’re meant to mimic your natural pancreatic enzymes, replacement digestive enzymes must be taken just before you eat. That way, they can do their work as food hits your stomach and small intestine.

What should not be taken with digestive enzymes?
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What should not be taken with digestive enzymes?

  • The effectiveness of oral digestive enzymes may decrease when they are given with calcium or magnesium containing antacids.
  • Digestive enzymes containing amylase or other carbohydrate digesting enzymes may reduce the effectiveness of alpha-glucosidase inhibitors (for example, acarbose ( Precose ), miglitol ( Glyset )), a class of oral anti- diabetes medications that are used to reduce the activity of the carbohydrate digesting enzymes.

Are oral digestive enzymes available over-the-counter (OTC)?

Digestive enzymes are available over-the-counter (OTC) or by prescription.

What happens if you take digestive enzymes on an empty stomach?
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What happens if you take digestive enzymes on an empty stomach?

If food is not able to be absorbed, it may cause gastrointestinal issues. When taking digestive enzymes, this can help the production of digestion and absorption, relieving GI distress.

Who here hates feeling tired throughout the day? I know I do.

A common symptom of enzyme deficiency is constantly feeling sluggish or tired. When broken-down food particles are absorbed into our body, it is also providing us with nutrients and energy. Being malnourished caused by digestive issues can lead to fatigue symptoms.

Do digestive enzymes flatten stomach?
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Do digestive enzymes flatten stomach?

Although some small studies suggest that digestive enzymes may help reduce bloating and other gastrointestinal (GI) symptoms, there is not enough clinical evidence to support this.

Digestive enzymes are complex proteins the body naturally produces in the GI system to help break down food for absorption. A person can also take digestive enzymes as supplements in tablet or pill form.

More research is necessary to find out whether digestive enzyme supplements can help reduce bloating.

This article looks at what digestive enzymes are, what they do, whether they can help with bloating, and who might benefit from taking them.

Is it better to take probiotics or digestive enzymes?
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Is it better to take probiotics or digestive enzymes?

Digestive enzymes and probiotics are very different and affect gut health in different ways. The two actually complement each other: Digestive enzymes improve the processes of digestion while probiotics keep the digestive environment healthy. Having too little of either one is detrimental to gut health.

Probiotics are living microorganisms, and there are billions of them living in the gut. Often referred to as “good gut bacteria,” probiotics support not only digestion and absorption, but also the immune system and neurotransmitter production, to name a few.

When you consume foods with probiotics like yogurt, sauerkraut, or kimchi, the beneficial bacteria primarily work to prevent an overgrowth of harmful bacteria. Probiotics also support a strong gut barrier to prevent pathogens from entering the blood. Another interesting probiotic function is their role in creating certain vitamins.

What is the correct way to take digestive enzymes?
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What is the correct way to take digestive enzymes?

Take this medication by mouth with meals and snacks as directed by your doctor.

The dosage is based on your medical condition, diet, and response to treatment.

If you are using the tablet form of the medication, make sure not to keep it in the mouth because doing so can cause irritation to the gums and cheeks. Swallow the medication with water. For the chewable tablets, chew thoroughly before swallowing.

If you are using the capsule form of the medication and swallowing is difficult, the capsule may be opened and the powder mixed with food or liquid.

Be careful not to inhale any of the powder because doing so can irritate the inside of the nose or cause an asthma attack.


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Can Digestive Enzymes Be Taken With Antacids?
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Elle Pierson

Hi, I’m Elle Pierson, RN, MBA—a passionate Healthcare Consultant dedicated to empowering individuals and organizations to achieve better health outcomes. As a TEDx Speaker, Author, and Mentor, I bring my expertise in medicine and healthcare management to help others navigate complex systems with confidence. My mission is to inspire change and create meaningful solutions in the world of healthcare. Thank you for joining me on this journey!

Education: Bachelor of Science in Nursing (BSN) and Executive MBA from Texas Woman’s University.
Email: [email protected]

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