Do Elevated Liver Enzymes Result With Trokendi Xr?

Trokendi XR, an anticonvulsant medication used for epilepsy and migraine, contains topiramate, which can cause some unwanted side effects. Liver problems can increase the risk of high ammonia levels in the blood during treatment, which can lead to serious side effects such as weight loss. Topiramate may also cause liver enzymes to increase three times from the baseline, which can affect mental activities.

Topiramate has been rarely associated with hepatic injury and is often used in combination with other anticonvulsant medications. However, it can cause mild or serious side effects, including high blood ammonia levels, which can affect mental activities. It also interferes with the metabolism of the antipsychotic medication, leading to hepatotoxicity, which is thought to involve inducing the CYP3A4 enzyme.

Topiramate is used to prevent migraine headaches in adults and adolescents 12 years and older. However, it does not affect liver enzymes and has not been associated with hepatotoxicity. Vigabatrin (VBN) is excreted unchanged by the kidneys without undergoing any kidney function tests.

In summary, Trokendi XR, an anticonvulsant medication, can cause various side effects, including liver problems, weight loss, and potential side effects like high blood ammonia levels, shortness of breath, and suicidal ideation. It is important to consult a healthcare provider to ensure the information displayed on this page applies to your personal needs.

What antidepressants cause elevated liver enzymes?

Results:. The study revealed that incidence rates of drug-induced liver injury were highest during treatment with mianserine (0. 36%), agomelatine (0. 33%), and clomipramine (0. 23%). The lowest probability of drug-induced liver injury occurred during treatment with selective serotonin reuptake inhibitors ((0. 03%), especially escitalopram (0. 01%), citalopram (0. 02%), and fluoxetine (0. 02%)). The most common clinical symptoms were nausea, fatigue, loss of appetite, and abdominal pain. In contrast to previous findings, the dosage at the timepoint when DILI occurred was higher in 7 of 9 substances than the median overall dosage. Regarding liver enzymes, duloxetine and clomipramine were associated with increased glutamat-pyruvat-transaminase and glutamat-oxalat-transaminase values, while mirtazapine hardly increased enzyme values. By contrast, duloxetine performed best in terms of gamma-glutamyl-transferase values, and trimipramine, clomipramine, and venlafaxine performed worst.

Conclusions:. Our findings suggest that selective serotonin reuptake inhibitors are less likely than the other antidepressants, examined in this study, to precipitate drug-induced liver injury, especially in patients with preknown liver dysfunction.

Keywords: Adverse drug reaction, antidepressants, drug surveillance, elevation of liver enzymes.

Does Trokendi affect the liver?

Conclusion. Topiramate is thought to be rarely associated with liver injury and by and large known to cause liver toxicity in conjunction with other anticonvulsants. Here, we report a case of acute asymptomatic elevation of liver enzymes in an adult caused solely by topiramate which, to the best of our knowledge, has not been reported before. Further to this, we recommend monitoring patients on topiramate for liver enzymes whenever feasible especially when on concomitant drugs labeled to cause liver injury.

Conflicts of interest. There are no conflicts of interest.

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Can Topamax cause elevated liver enzymes?

Hepatotoxicity. Prospective studies suggest that less than 1% of subjects develop elevations in serum aminotransferase levels during long term topiramate therapy. Clinically apparent hepatotoxicity from topiramate is quite rare and usually arises in patients receiving multiple other anticonvulsants. Topiramate is metabolized by CYP 3A4 and may increase the risk of valproate or other anticonvulsant hepatotoxicity. A distinctive syndrome is the development of lethargy, weakness with marked serum aminotransferase elevations and hyperammonemia arising within 2 to 3 weeks of the addition (or dose increase) of topiramate to long term valproate therapy. While valproate alone can cause a similar syndrome, it appears much more common (~1%) with the combination than with valproate alone (~0. 1%). This syndrome has several features suggestive of Reye syndrome (hyperammonemia, hypoglycemia, rapid reversal of injury) and in many instances is preceded by a acute viral illness. Topiramate by itself has only rarely been linked to clinically apparent liver injury and the clinical features and course of injury have not been well defined. Topiramate has not been linked to cases of the anticonvulsant hypersensitivity syndrome and is considered a safe alternative in patients with that syndrome.

Likelihood score: C (probable rare cause of clinically apparent liver injury).

Mechanism of Injury. The mechanism of topiramate hepatotoxicity is thought to be due to its effects in inducing CYP 3A4 or inhibiting CYP 2C19 and possibly through the effects of a toxic metabolic intermediate. Cases with lactic acidosis and hyperammonemia may be caused by mitochondrial injury or dysfunction.

Can migraine medication cause liver damage?

Hepatotoxicity. In large prospective controlled trials, the different triptans have not been associated with serum enzyme elevations or hepatotoxicity; however, the frequency of monitoring in most studies was limited and rates of ALT elevations not reported. There have been rare individual reports of cholestatic hepatitis after the use of triptans, largely associated with zolmitriptan. Typically, the onset of injury was within 1 to 2 weeks of taking several doses of the zolmitriptan for a protracted and severe migraine attack. Recurrent jaundice with intermittent therapy has also been reported (Case 1). The pattern of serum enzyme elevations was mixed or cholestatic, and recovery was complete within 1 to 2 months. Allergic manifestations (rash, fever, eosinophilia) were not present and autoantibodies did not develop.

Likelihood score, zolmitriptan: D (probable rare cause of clinically apparent liver injury).

Likelihood score, rizatriptan: E* (suspected but unproven cause of liver injury).

Can Ozempic cause liver problems?

Summary: Ozempic and other GLP1 agonists are associated with a reduced risk of developing cirrhosis and liver cancer in people with type 2 diabetes and chronic liver disease, according to a nationwide study.

Ozempic and other GLP1 agonists are associated with a reduced risk of developing cirrhosis and liver cancer in people with type 2 diabetes and chronic liver disease, according to a nationwide study from Karolinska Institutet in Sweden published in the journal Gut.

GLP1 agonists like Ozempic reduce blood sugar levels and are mainly used to treat type 2 diabetes. However, as the drug also reduces appetite, it is now increasingly used to treat obesity and has become a popular weight-loss drug.

Results from early clinical trials also suggest that GLP1 agonists may reduce the risk of liver damage. Therefore, researchers at Karolinska Institutet included all people in Sweden with chronic liver disease and type 2 diabetes in a register-based study. They then compared the risk of severe liver damage in those who were treated with GLP1 agonists and those who were not. The results show that those who took the drug for a long period of time had a lower risk of later developing more severe forms of liver disease such as cirrhosis and liver cancer.

Why do I have high liver enzymes?

Elevated liver enzymes often are a sign of inflamed or damaged cells in the liver. Inflamed or injured liver cells leak higher levels of certain chemicals into the bloodstream. These chemicals include liver enzymes that may appear higher than usual on blood tests.

What are the 10 worst medications for your liver?

Prescription drugs:Statins. Antibiotics like amoxicillin-clavulanate or erythromycin. Arthritis drugs like methotrexate or azathioprine. Antifungal drugs. Niacin. Steroids. Allopurinol for gout. Antiviral drugs for HIV infection.

Toxic liver disease, or drug-induced liver injury (DILI), is damage to your liver. It’s also called hepatotoxicity or toxic hepatitis. It can cause serious symptoms or liver damage if you don’t get help.

Medications, herbal supplements, chemicals, solvents, and alcohol are all possible causes of hepatotoxicity.

Your liver filters everything that goes into your body. It clears out alcohol, drugs, and chemicals from your blood. Then it processes the unwanted bits so you can flush them out through your urine or bile.

Can the pill cause high liver enzymes?

Hormonal contraceptive users have been found to have a significantly higher mean value of liver enzymes compared to non-user control groups. Hormonal contraceptives are artificial preparations containing artificial progestins and Ethinylestradiol used by women of reproductive age to prevent pregnancy. However, these contraceptives are linked with adverse effects, including disturbances of liver functionality and integrity. Previous studies have reported conflicting results on the association between hormonal contraceptive utilization and liver function tests. A study involving 264 participants enrolled in two groups: those using the medication for a minimum of six months, and those using a non-user control group. A semi-structured questionnaire was used to collect socio-demographic, behavioral, and clinical data. Liver function tests were performed on five ml serum blood samples. The study concluded that hormonal contraceptive use affects hepatic function and recommends closely monitoring liver function tests in women using hormonal contraceptives.

Can bupropion raise liver enzymes?

Bupropion is an aminoketone antidepressant widely used in depression and smoking cessation therapy. It is associated with transient, usually asymptomatic elevations in serum aminotransferase levels and has been linked to rare instances of clinically apparent acute liver injury. Bupropion has no activity against monamine oxidase and appears to act via noradrenergic or dopaminergic mechanisms. It was approved for use in moderate and severe depression in the United States in 1985 and later for seasonal affective disorder and aiding smoking cessation. Currently, approximately 4 million prescriptions are filled yearly. Bupropion is available in immediate and sustained release tablets of 75, 100, 150, 200, and 300 mg in several generic forms and under the brand name Welbutrin. The recommended dosage for depression in adults is 75 to 300 mg daily, while separate formulations of sustained release forms are available for smoking cessation. Common side effects of bupropion include drowsiness, dizziness, agitation, headache, nausea, abdominal pain, and dry mouth.

Hepatotoxicity has been reported in less than one in three patients on bupropion, with liver test abnormalities occurring in less than one in less than one patient. The onset of injury is usually within 1 to three months, and the pattern of serum enzyme elevations has been variable. Autoimmune (autoantibodies) are found in a proportion of cases, but in low titer. Immunoallergic features are uncommon. The injury is generally self-limited, but fatal cases have been reported.

Can contrave cause elevated liver enzymes?

Liver damage or hepatitis Contrave contains the generic drug naltrexone. In clinical trials, naltrexone has been reported to cause hepatitis and other liver problems. Symptoms of liver problems include abdominal pain lasting more than a few days, dark urine, yellowing of the whites of the eyes, and tiredness.

. Contrave is a brand-name prescription drug. It’s FDA-approved to help adults lose weight when combined with a balanced diet and exercise.

This drug has certain limitations of use as well as minimum body mass index (BMI) requirements. (BMI is an estimate of a person’s body fat based on height and weight.) To learn more, see the ” Contrave for weight loss and weight management ” section below.

Drug details. Contrave contains two active drugs: naltrexone and bupropion. Naltrexone is in a class of drugs called opioid antagonists, and bupropion is in a class called antidepressants.

Can epilepsy medication affect your liver?

This article discusses the treatment of seizures in patients with advanced liver disease, focusing on the acute and chronic treatment of these conditions. It discusses the hepatotoxic potential of specific antiepileptic drugs, highlighting the importance of considering the pharmacokinetic profile and hepatotoxic potential when choosing the most appropriate antiepileptic drug. Newer antiepileptic drugs without or with minimal hepatic metabolism, such as levetiracetam, lacosamide, topiramate, gabapentin, and pregabalin, should be used as first-line therapy. Medications undergoing extensive hepatic metabolism, such as valproic acid, phenytoin, and felbamate, should be used as drugs of last resort. In special circumstances, such as acute intermittent porphyria, exposure to most antiepileptic drugs could precipitate attacks. In the treatment of status epilepticus, levetiracetam and lacosamide are good second-line therapies after benzodiazepines fail to control seizures. Hepatotoxicity is a rare and unexpected side effect of some antiepileptic drugs, with valproic acid, phenytoin, and felbamate having a well-recognized association with liver toxicity. Physicians should be mindful of the pharmacokinetic profile and hepatotoxic potential of different antiepileptic drugs to ensure the best treatment for patients with liver disease.