Does Extract From Nettle Roots Increase Liver Enzymes?

Nettle extract consumption can increase the level of liver peroxysomal acyl oxidase 1 (ACOX), a transcriptional factor in the liver. Despite its widespread use, there have been no reported reports of serum enzyme elevations or clinically apparent liver injury attributable to nettle extract. Stinging nettle is a nutritious plant popular in Western herbal medicine, known for its potential to reduce inflammation, hay fever symptoms, blood pressure, and blood sugar levels. It is most commonly used for diabetes and osteoarthritis, and may also be used for urinary tract infections (UTIs), kidney stones, and enlarged blood vessels. Stinging nettle may interact with drugs metabolized by cytochrome P450 enzymes, including Warfarin. It has antiproliferative, anti-inflammatory, antioxidant, analgesic, anti-infectious, hypotensive, and anti-ulcer characteristics. Stinging nettle has been used for centuries to treat painful muscles and joints, eczema, arthritis, gout, and anemia. Nettle, a plant with a long history as an herbal remedy and nutritional supplement, has been shown to decrease enzyme levels in rats fed a high-fat diet.

What is the best herb for liver repair?

What herbs can help improve liver health? Milk thistle, turmeric, and burdock are three supplements often used to improve liver health. Of the three, milk thistle has the most evidence to support it can benefit liver health.

Many proponents of herbal medicine suggest using herbs to enhance the health of your liver, an organ responsible for clearing toxins from your body. Indeed, some research shows that certain herbs may help fight liver disorders like cirrhosis (scarring of the liver) or infections like hepatitis B and hepatitis C (causes of liver inflammation).

Here’s a look at several herbs that show promise as a natural means of boosting liver health.

Milk Thistle. Milk thistle may benefit people with cirrhosis of the liver, according to a report published in 2001.   Analyzing five clinical trials (with a total of 602 cirrhosis patients), researchers determined that treatment with milk thistle could lead to a significant reduction in liver-related mortality.

What are the side effects of nettle root extract?

Stinging nettle is generally considered safe when used as directed. Occasional side effects include mild stomach upset, fluid retention, sweating, diarrhea, and hives or rash (mainly from topical use). It is important to be careful when handling the nettle plant because touching it can cause an allergic rash. Stinging nettle should never be applied to an open wound.

Because nettle can alter the menstrual cycle and may contribute to miscarriage, pregnant women should not use nettle.

DO NOT self treat with nettle for BPH. See your doctor to receive a diagnosis and to rule out prostate cancer.

How much nettle root extract per day?

Stinging nettle has historically been used for joint pain and has been shown to be safe and effective for relieving the pain of osteoarthritis.

Has historically been used for joint pain. Topical application with the intent of causing stings to relieve joint pain has been assessed in preliminary and double-blind trials. The results found intentional nettle stings to be safe and effective for relieving the pain of osteoarthritis. The only reported adverse effect is a sometimes painful or numbing rash that lasts 6 to 24 hours.

Stinging nettle enriches and increases the flow of breast milk and restores the mother’s energy following childbirth.

Does nettle leaf reduce creatinine?

• Fruits: Antioxidant-rich options like cranberries, kiwi, apples and blueberries aid in lowering creatinine levels.
• Vegetables: Including a variety of vegetables like bitter gourd, eggplant, carrot, cauliflower, red bell pepper, cucumber and onions helps regulate creatinine levels.
• Spices: Cinnamon, known for its kidney-friendly properties, can be added to the diet to help manage creatinine levels.
• Nettle Leaf Tea: Consuming 1-2 cups a day can serve as a powerful kidney tonic, potentially improving kidney function and reducing serum creatinine levels.
• Plant-Based Proteins: Consider substituting some or all of your animal protein sources with plant-based options like beans, lentils, and tofu.

The nutrition expert revealed, “These foods not only provide valuable plant-based protein but are also recommended as part of a kidney-friendly diet to manage creatinine levels and promote overall kidney health. Research has indicated that high-quality protein sources like beans, lentils, and tofu can enhance kidney function and decrease the risk of kidney disease. Additionally, these options are low in potassium, which is crucial for individuals with kidney disease who need to monitor their potassium intake.”

How long can you safely take nettle?

When taken by mouth: Stinging nettle is possibly safe when used for up to 1 year. It might cause diarrhea, constipation, and upset stomach in some people. When applied to the skin: Stinging nettle is possibly safe. Touching the stinging nettle plant can cause skin irritation.

Stinging nettle (Urtica dioica) is a plant with pointed leaves and white to yellowish flowers. The root and above ground parts are used for diabetes.

The stinging nettle plant is typically 2-4 meters tall. It contains ingredients that might decrease swelling and increase urination. The leaves are sometimes eaten as a cooked vegetable.

Stinging nettle is most commonly used for diabetes and osteoarthritis. It is also sometimes used for urinary tract infections ( UTIs ), kidney stones, enlarged prostate, hay fever, and other conditions, but there is no good scientific evidence to support these uses.

What supplements can cause elevated liver enzymes?

Herbal supplements and vitamin supplements, like chaparral, comfrey tea, iron and vitamin A.

What does it mean to have elevated liver enzymes?. If you have high levels of liver enzymes in your blood, you have elevated liver enzymes. High liver enzyme levels may be temporary, or they may be a sign of a medical condition like hepatitis or liver disease. Certain medications can also cause elevated liver enzymes.

What are liver enzymes?. Liver enzymes are proteins that speed up chemical reactions in your body. These chemical reactions include producing bile and substances that help your blood clot, breaking down food and toxins, and fighting infection. Common liver enzymes include:

• Alkaline phosphatase (ALP).
• Alanine transaminase (ALT).
• Aspartate transaminase (AST).
• Gamma-glutamyl transferase (GGT).

Is nettle hard on the kidneys?

• Nettle tea benefits the kidneys by increasing urine output and uric acid removal. Because of its anti-inflammatory properties, it improves kidney function and urinary flow.
• Nettle tea is a natural diuretic that promotes proper fluid flow in the kidneys and bladder, preventing kidney stones from forming.
• According to research, nettle tea can help flush toxins from the urinary tract as well as support the medications used to treat urinary tract infections.
• Few studies report that nettle can slow the multiplication of prostate cells in the same way that finasteride (a medication used to treat benign prostatic hyperplasia ) does. This herb has been approved for the treatment of symptoms such as decreased flow rate, painful urination, and so on. It can inhibit the prostatic conversion of testosterone to dihydrotestosterone), thereby aiding in the reduction of prostate size in hypertrophy.

Nettle tea can help with indigestion, nausea, excess gas, colitis, and celiac disease. It also prevents diarrhea by killing parasites and worms in the intestine.;

• Herbalists recommend nettle tea for hair growth, claiming that the silica in nettles strengthens hair and nails, and its other properties improve circulation and decrease shedding.
• Nettle tea may help in skin conditions such as eczema and rashes.
• According to some studies, nettle tea can help treat hives and urticaria. While the nettle leaf hair contains histamine and frequently causes hives, the extract of the leaves may contain compounds that can soothe hives by turning off the inflammatory response.

What herbs can cause elevated liver enzymes?

Herbal supplements. How could something natural be bad for your liver? In fact, some common herbs could cause toxic liver disease. Watch out for supplements that contain aloe vera, black cohosh, cascara, chaparral, comfrey, ephedra, or kava.

Chemicals and solvents. Some workplace chemicals can harm your liver. Some examples are vinyl chloride, which is used to make plastics; a dry cleaning solution called carbon tetrachloride; the weed killer paraquat; and polychlorinated biphenyls.

You may be more likely to get toxic liver disease if:

Is nettle root good for liver?

This study aimed to evaluate the interaction between nettle (Urtica dioica L.) water extract consumption and regulators of peroxysomal lipid oxidation, histone deacetylase, and markers of oxidative stress in the liver and blood lipid levels in male and female C57Bl6 mice. The mice were treated with nettle extract in a dose of 40 mg of total polyphenols per kg mice body weight and applied daily along with normal diet for 15 days. The serum triglycerides, cholesterol, HDL, LDL, and liver PPAR-α, PPAR-γ, PGC-1-α, ACOX1, SIRT1, MDA, SOD, CAT, and GSH were compared between exposed and unexposed (control) animals.

In males, the PPAR-α, PGC1-α, and ACOX1 levels together with systemic HDL cholesterol were significantly increased while the LDL cholesterol decreased. In females, no changes in PPAR-α and PGC1-α or serum lipids were noted, but the ACOX1 content in the liver was significantly increased. The SIRT1 activity increased only in females. In both sexes, the PPAR-γ levels were not significantly affected in either sex.

The results indicate that nettle plant extract has the potential to modulate selected transcriptional factors and histone deacetylase in vivo, with certain sex differences. Further studies in similar models are needed to understand the potential benefits of nettle consumption in managing cholesterol, dyslipidemia, and oxidative stress.

Who should not take nettle?

Risks. Avoid stinging nettle if you’re allergic or sensitive to nettle or plants in the same family.

Avoid if you’re pregnant or breastfeeding because there isn’t enough information on its safety.

Use with caution if you’re elderly because of the potential of causing low blood pressure.

And use stinging nettle with caution if you have diabetes because of the potential that it may lower or raise blood sugar levels.

Interactions. Stinging nettle may interact with some medications, so use with caution if you’re taking:

Can dandelion root cause elevated liver enzymes?

Dandelion root extract has been found to have protective effects against alcohol-induced liver damage in ICR mice and HepG2/2E1 cell lines without any cytotoxic effects. The extract significantly reduced serum AST, ALT, ALP, lactate dehydrogenase, and malondialdehyde (MDA) levels and increased hepatic antioxidant enzymes. This reduction in lipid peroxidation and increase in antioxidant enzymes were caused by the dandelion hot water extract.

Dandelion leaf extract has also been confirmed to have hepatoprotective effects against sodium dichromate-induced liver injury in rats. Oral daily administration of dandelion leaf hot water extract (500 mg/kg) for 30 days decreased total cholesterol, triglycerides, AST, ALT, lactate dehydrogenase, MDA, and chromium concentrations in rat’s blood and liver. Thyroid-stimulating hormone levels reached normal levels in sodium dichromate treated animals after pretreatment with dandelion leaf extract, which was associated with an increase in antioxidant enzyme activities and reduction in DNA fragmentation.

Dandelion is used in combination with other herbal extracts as hepato-protective agents, commonly used in combination with Silybum marianum (S. marianum). The protective effect of oral dandelion extract (100 mg/kg/day) and its combination with S. marianum extract (100 mg/kg/day) was evaluated in CCL 4 treated female Wistar albino rats. The combination of dandelion and S. marianum extracts in CCl 4 treated animals decreased serum ALP and GGT enzyme activities and MDA level in the kidney tissue, and increased the GSH level and GST enzyme activities.

The hepatoprotective effects of dandelion are confirmed in animal studies, but there is no clinical study on its efficacy. It would be worthwhile to know the chemical compounds responsible for its hepatoprotective effects and choose these compounds as standard for clinical trials.

Among different parts of dandelion extracts, aqueous extracts of dandelion roots and leaves have been used as hepatoprotective agents. The main components of dandelion leaf extract include total phenolics, flavonoids, tannins, polysaccharides, and ascorbic acids.