Vyvanse, also known as lisdexamfetamine, is a prodrug that requires hydrolysis to convert into its active form in the liver. Liver enzymes are crucial for the medication’s effectiveness. A liver biopsy showed cholestatic hepatitis with zone 3 hepatocellular and canalicular cholestasis, consistent with DILI. Vyvanse does not affect liver enzymes, but high doses of amphetamines can cause liver injury. Long-term use of Vyvanse can potentially affect liver enzymes, especially when combined with a poor diet. Vyvanse is metabolized by CYP2D6, an enzyme in the liver. Certain drugs can reduce the activity of this enzyme, known as atomoxetine (Strattera). Methylphenidate has been linked to a low rate of serum aminotransferase elevations during therapy and to rare instances of acute, clinically apparent liver damage. Medications may cause liver enzymes to be elevated without serious damage until they reach 3 to 5 times the normal levels. Long-term liver damage can occur in people who abuse Vyvanse, causing fatigue, itching, confusion, and a yellow tint to their skin.
| Article | Description | Site |
|---|---|---|
| Have your liver levels changed? : r/VyvanseADHD | I take Vyvanse myself and have normal liver enzyme levels. To the best of my knowledge, Vyvanse does not affect liver enzymes. It is recommended that you consult with your physician regarding the following: | www.reddit.com |
| Amphetamines – LiverTox | The administration of high doses of amphetamines has been linked to the occurrence of liver injury, as well as the development of distinctive forms of clinically apparent liver injury. | www.ncbi.nlm.nih.gov |
| “A Case of Suspected Lisdexamfetamine (Vyvanse) Drug … | Amphetamines are a well-established cause of liver injury. However, the typical presentation is that of illicit drug abuse rather than liver injury occurring as a direct result of the drug itself. | jdc.jefferson.edu |
📹 3 Things To Know Before Using Vyvanse (Lisdexamfetamine)
In this episode, I discuss a medication known as Vyvanse (Lisdexamfetamine) and go over three things that you should know …
What would cause high liver enzymes?
Common causes of elevated liver enzymes include:Nonprescription pain medicines, particularly acetaminophen (Tylenol, others). Certain prescription medicines, including statins, which are used to control cholesterol. Drinking alcohol. Heart failure. Hepatitis A. Hepatitis B. Hepatitis C. Nonalcoholic fatty liver disease.
What can falsely elevate liver enzymes?
Common causes of elevated liver enzymes include: Nonprescription pain medicines, particularly acetaminophen (Tylenol, others). Certain prescription medicines, including statins, which are used to control cholesterol. Drinking alcohol.
What deficiencies can Vyvanse cause?
To understand how pharmaceutical drugs deplete vitamins and nutrients, it’s important to understand how your medicine works. Stimulant drugs like Adderall and Vyvanse may help to relieve feelings of sadness or overwhelm, but they can also deplete stores of magnesium in the body. Magnesium is a key element for maintaining your mental health, so this can be problematic.
Medications may also work against your body by blocking the absorption of vitamins as well as the storage and metabolism of those nutrients.
To learn more about specific nutrients and which drugs might deplete or block them, check out our drug-induced nutrient depletion chart below.
What organs does Vyvanse affect?
In rare cases, Vyvanse can cause side effects that last longer or that cause long-term problems. These effects can include: cardiovascular (heart and blood vessel) problems, including increased blood pressure, heart attack, and stroke* blood circulation problems in your fingers and toes, including Raynaud’s disease*
Vyvanse (lisdexamfetamine) is a brand-name drug that’s prescribed for ADHD and for binge eating disorder. As with other drugs, Vyvanse can cause side effects, such as headache or sleep problems.
Vyvanse belongs to a drug class called central nervous system stimulants. The drug is not available in a generic version. Vyvanse is available in these forms:
Read on to learn about potential common, mild, and serious side effects of Vyvanse. For a general overview of the drug, including details about its uses, see this article.
Why are my liver enzymes elevated all of a sudden?
Elevated liver enzymes often are a sign of inflamed or damaged cells in the liver. Inflamed or injured liver cells leak higher levels of certain chemicals into the bloodstream. These chemicals include liver enzymes that may appear higher than usual on blood tests.
What chemicals does Vyvanse affect?
Vyvanse works by altering the balance of chemicals in your brain and increasing norepinephrine and dopamine levels. Norepinephrine is a stimulant, and dopamine is a naturally occurring substance that stimulates feelings of pleasure and reward.
If you have ADHD, you may notice an improvement in your attention span. It can also help control hyperactivity and impulsiveness and improve concentration. It’s also used off label for treatment resistant depression and narcolepsy. It may improve depression, fatigue, sleepiness and wakefulness.
When used to treat binge-eating disorder, Vyvanse may help you binge less frequently.
Common side effects in the central nervous system include:
Can ADHD meds cause elevated liver enzymes?
Methylphenidate is a central nervous system stimulant used for treating attention deficit disorder and narcolepsy. It is structurally related to amphetamine and acts as a sympathetic stimulant, causing the release of norepinephrine at CNS nerve terminals, promoting neurotransmission. Therapy with methylphenidate has been shown to increase cognitive abilities and improve psychological functioning in children and adults with suspected attention deficit disorders. It has a paradoxical calming action in children with hyperactivity. Methylphenidate was approved for use in the United States for attention deficit disorder in adults in 1955 and has been broadened to include children above the age of 6 and adolescents with attention deficit disorder.
The usual initial dose of standard oral methylphenidate in adults is 10 mg two times daily, and average maintenance dosage is 40 to 60 mg daily in 2 or 3 divided doses. The dosage in children varies by formulation. Methylphenidate is a controlled substance (Schedule II) and has abuse potential. Common side effects include headache, insomnia, irritability, palpitations, tachycardia, nasal stuffiness, decreased appetite, nausea, cough, and rash. Uncommon but potentially severe adverse events include psychotic symptoms, cardiovascular events, abuse and dependence, and reduced adult height in children with long-term therapy.
Hepatotoxicity has been linked to methylphenidate, with low rates of serum aminotransferase elevations during therapy and rare instances of acute, clinically apparent liver injury, generally after intravenous abuse. Immunoallergic features are uncommon, and some cases have been severe, with at least one fatality after intravenous abuse. Recurrence upon rechallenge has been documented in one instance.
Can Vyvanse cause liver problems?
Abstract. Amphetamines are a well-established cause of liver injury though the typical presentation is that of illicit drug abuse rather than liver injury occurring in a prescribed setting. 1 Lisdexamfetamine (Vyvanse) is one of the most commonly prescribed stimulant medications used for the treatment of Attention Deficit Hyperactive Disorder (ADHD). The authors were only able to find a single case of lisdexamfetamine-related drug-induced liver injury (DILI) occurring in the pediatric population in their review of the literature. Here we present a case of suspected lisdexamfetamine DILI in an adult patient.
Kishfy, MD, Louis; Bilello, MD, Justin; Ahmed, MD, Monjur; and Flerova, MD, Elizaveta”A Case of Suspected Lisdexamfetamine (Vyvanse) Drug-Induced Liver Injury,” The Medicine Forum : Vol. 24, Article 12. DOI: doi. org/10. 29046/TMF. 024. 1. 011 Available at:jdc. jefferson. edu/tmf/vol24/iss1/12.
Is Vyvanse safe long term?
Vyvanse may also cause more serious side effects, including heart attack, stroke, and mental health conditions like depression and psychosis. These may be long-term effects. Speak with a doctor if you experience these severe side effects.
Vyvanse (lisdexamfetamine) is a prescription drug used to treat ADHD and binge eating disorder. Vyvanse can cause side effects that range from mild to serious. Its side effects are usually the same for males and females.
- Attention deficit hyperactivity disorder (ADHD) in adults and certain children
- moderate to severe binge eating disorder in adults
The active ingredient in Vyvanse is lisdexamfetamine. (An active ingredient is what makes a drug work.) The drug is taken by mouth and is available as a capsule that you swallow or a chewable tablet.
What are the 10 worst medications for your liver?
Prescription drugs:Statins. Antibiotics like amoxicillin-clavulanate or erythromycin. Arthritis drugs like methotrexate or azathioprine. Antifungal drugs. Niacin. Steroids. Allopurinol for gout. Antiviral drugs for HIV infection.
Toxic liver disease, or drug-induced liver injury (DILI), is damage to your liver. It’s also called hepatotoxicity or toxic hepatitis. It can cause serious symptoms or liver damage if you don’t get help.
Medications, herbal supplements, chemicals, solvents, and alcohol are all possible causes of hepatotoxicity.
Your liver filters everything that goes into your body. It clears out alcohol, drugs, and chemicals from your blood. Then it processes the unwanted bits so you can flush them out through your urine or bile.
Is Vyvanse metabolized in the liver?
After oral administration, lisdexamfetamine dimesylate is rapidly absorbed from the gastrointestinal tract. Lisdexamfetamine dimesylate is converted to dextoamphetamine and L- lysine, which is believed to occur by first-pass intestinal and/or hepatic metabolism.
📹 ADDERALL: Doctors Guide to Side Effects
Adderall or the generic name amphetamine/dextroamphetamine is a stimulant medication that is approved to treat Attention Deficit …
I’ve been on Vyvanse a couple times. In my experience (and this will vary person to person, obviously) Vyvanse is kind of an odd medication. Some days it seems to work really well and some days it seems to hardly work at all. I’m sure its due to a number of factors including other medications I take and how my body metabolizes the Vyvanse. Just thought I would mention this in case anyone else is going to start taking it and that they might experience the same.
It’s pretty important to know about the crash you can get when the Vyvanse starts wearing off. In patients with depression the crash has a major effect on mood & is likely to exacerbate the depression at least until the crash has passed. This would be one of the first things I’d tell someone wanting to start Vyvanse. It’s an effective drug that helps many people & I respect that. I myself am on Vyvanse so note I’m speaking from my own experience but experiencing a crash from the drug is a common side effect.
I’m currently on Vyvanse and the main things I’ve noticed (good and bad) are: Extreme loss in appetite (sometimes i cant stomach any food at all) Upped concentration and focus (only sometimes though) Anxiety? (I think this medication has made me a bit more anxious, which isn’t normal as usually I’m pretty confident)
Vyvanse is a 100 million times better than methylphenidate at least for me personally. It’s abuse proof, doesn’t cause any addictive euphoric rush, and genuinely helps me survive day to day. It’s kinda like what caffeine is for normal people, or kinda like it’s depicted in movies. I still have appetite, and have actually gained a bit of weight back after my malnutrition health disaster on methylphenidate. But on some days it feels like it’s not working at all. I feel like it’s the lysine shell that’s causing it, maybe it just doesn’t metabolize on some days. For some reason on some days it feels like it’s working waay too much, and on some days it feels like I’ve taken a sugar pill and fall asleep throughout the day with the same crazy brain fog and fatigue that I had before I was diagnosed.
Just want to add in the overlooked aspect of taking Vyvanse. You need to stay hydrated, eat well even if you have to force it and sleep sufficiently, these three things help your body process the medicine efficiently, reduces the potency of the crash, and the recovery time from crash to normal is way quicker. Hope this helps!
I was on Vyvanse for several years and it was terrible. I wouldn’t eat throughout the day and would binge eat at night. Not to mention the sleep disruption despite taking my dose at 6:30am. About 6 months ago I was shifted onto a faster acting dexamfetamine and it’s so much better. I take my first dose at 6:30am and it’s worn off by lunch time so I can eat and then take my afternoon dose. Plus if I don’t have a busy day I can break the tablet in half and just have a half dose. It’s so much better than Vyvanse
I feel like I’m losing it but can’t put it in words my sensory overload my anxiety is worse then before I can’t sleep losing my appetite feels like everything is loud and lights are bright also feels like people are mad at me and they are talking bloody loud 😂😂my mind is running to fast if anyone can understand this message please comment under it if it’s normal or if it’s not what the meds should be feeling like. 😊
Vyvanse has been a benefit to me throughout the years that I have taken the med – I was first prescribed at 13 and switched over to adderall at 16. I found that vyvanse suited my needs far better than adderall as well as the side effects were less than I had experienced when taking adderall. I took adderall for about a year and stopped because, at the time I had learned how to apply my focus through me experience using ADHD meds and I didn’t want to take it anymore. That worked and I was successful although there has also been times that it has taken a lot more effort to get my desired end result; that being said, I stopped take ADHD meds for 7 years and I started vyvanse again just recently. I have experienced loss in muscle tissue and heightened loss in appetite which I did not experience as a teenager. To curb these side effects I have increased my daily aerobic routine and have made an effort to eat at specific times in the day.
I find that I become a little bit sensitive with textures when I take my vyvanse! I don’t like eating meals aside from a big breakfast (before the medication) and diner. What helps is having multiple snacks that you can eat during the day! Having little crackers, apple sauce cups, fruits and smoothies allow me to “feed my medication” and small portions helps if the textures get too overwhelming. I hope this tip is helpfull. It’s not rocket science but sometimes it’s hard to identify how this lack of appetite manifest. I was told that it was because I was too focused but really, it was just that lunches didn’t do the trick anymore. (English is not my first langage sorry for the mistakes)
I took .5mg of Xanax yesterday due to some anxiety issues and was not on vyvanse. I took my normal dosage of vyvanse today and not only did I not get a positive feeling but I felt lethargic and spacey even. Has anyone else experienced this? I also didn’t eat before I took the meds as I took them right when I woke up.
I was prescribed vyv and given pamphlet for BED. I was already excersing but after my 3rd child 10yrs ago the weight refused to leave. Started@ lowest dose did NOT like how it made me feel. Every morning contemplated taking. Once I invested 💯 weight dropped. That outweighed the neg for me. I was diagnosed with ADD as adolescent prescribe meds never took them. So as an adult it was a win-win situation. Too bad there’s always back order. And out-of-pocket cost is in sane!! Any info on Optum coupon for this med? Good RX barely gives me a break.
This made wonders for me as i had a tendency for eating all day long and now only need a normal lunch. I also take it right before quitting for the job in the morning since morning fog during all AM was the main way my ADHD was affecting me at work. I take always the same 40mg which ended up being a sweet spot. i might take less if i feel less foggy or 50 if i had a bad sleep and need an extra boost, and if i happen to have a very good night of sleep and know the day will be quiet, I might skip it for a day, usually once a week. I also never take it on the weekend, and just assume i will likely be unproductive in the morning, so my body and brain can relax and reset.
Interesting, I’ve been on it for awhile now, it controlled my “anxiety comfort eating”, I sleep sooooo much better now before it just felt like my eyes were closed but my brain was still active, I’m only 5’4 and my heaviest was 180 and dropped to a healthier 145-150 not skin and bones maybe just a little chunky :3 The only downside for me is dry mouth 🙁 The way I take it which might help some people out to minimize some of the consistent usage symptoms or prevent a tolerance is I only take it days I work(for some it could be only days you have school).. I have tried taking it everyday once and yeah I didn’t like how it felt after awhile and didn’t feel like it was having the same effect. Don’t forget to drink water!!! Stay hydrated!!! A bit of electrolytes will come a long way.
Used Dexedrine for years till bout a month ago cause my Dr retired. I just quit it even though I had quite a bit left. Don’t know if I’ll even try to find someone else. Yes it worked for me but wasn’t a miracle. Used it as needed and never abused it. Friend of mine uses V. It’s extremely expensive and basically the same as Dexedrine with a lysine molecule attached to it so your body has to break it down first.
I started vyvanse this week oh god my mouth is so dry and it was so weird it was like anything that I put a slight of attention too even if I didn’t want too I just got sucked in I could block out stimulation around me like my biggest killer noise. But in the early hours of taking it I am extremely anxious, jittery like I just had caffeine on an empty stomach and close to a panic attack. Had a sense of impending doom that smth bad was gonna happen and for like 3 hours I was not able to function at all because the whole world felt fake, I didn’t feel real and all noise was just not even processing in my head, I couldn’t form my own words and I was slurring and stuttering like I was drunk. It was like a weird mixture of caffeine, sugar, drugs and alcohol 😭 AND MY MOUTH IS SO DRY ITS DRIVING ME INSANE. Hoping my body gets used to the meds quick luckily I had most of this week off of school I feel like I wanna bounce off of the walls and it is nearly 3 am I can’t sit still and I know I am supposed to be tired because I got bad sleep last night and woke up early, multiple times after trying to get back to sleep. Doesn’t help I also take iron which gives me pretty bad nausea and stomach aches and cramps so I feel awful but during school hours I feel so different like a shell of myself and I’m really dizzy. I am scarily underweight so I am on a strict food schedule to keep my weight up so I am not taken off of them also I have anger issues so I got told if they made me a angry and I started having behavioural issues that I’d be taken off of them then too.
Just be careful, tolerance builds and you have to increase dosages if you’re on it multiple times a week and when it stops working and you have no chemical help, ADHD/focus problems will get worse. All amphetamines can be neurotoxic in the long term and in high dosages, amphetamines downregulates your normal dopamime receptors, this can in the long term cause anhedonia, diminished drive, depression, tardive dyskinesia and certain psychotic disorders and in bad cases also brain damage, the effects of amphetamines on the brain is well studied. Just be careful, everything has pros and cons.